The author of 《Antimalarials. 9. Methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols》 were Markovac, A.; LaMontagne, M. P.. And the article was published in Journal of Medicinal Chemistry in 1976. Synthetic Route of C7H3Cl2NO3 The author mentioned the following in the article:
Nine di- and trisubstituted 9-phenanthrenemethanols bearing methylthio and methylsulfonyl substituents in the 2 and/or 6 positions of the phenanthrene nucleus were prepared and screened for antimalarial activity against Plasmodium berghei in mice. Six of the nine compounds were curative at or below 160 mg/kg. The most active structures contained a methylthio substituent in combination with two chlorine atoms. The most effective compound was 2,4-dichloro-α-dibutylaminomethyl-6-methylthio-9-phenanthrenemethanol-HCl (I) [59215-48-4]. The results came from multiple reactions, including the reaction of 3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0Synthetic Route of C7H3Cl2NO3)
3,5-Dichloro-2-nitrobenzaldehyde(cas: 59178-12-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Synthetic Route of C7H3Cl2NO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics