Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.; Dreher, Spencer D.; Tudge, Matthew T. published the artcile< Scope of the Palladium-Catalyzed Aryl Borylation Utilizing Bis-Boronic Acid>, Category: chlorides-buliding-blocks, the main research area is palladium catalyzed borylation aryl halide bisboronic acid; aryl fluoroborate preparation; boronic acid aryl preparation reaction; hydride reduction aryl halide palladium catalyst.
The Suzuki-Miyaura reaction has become one of the more useful tools for synthetic organic chemists. Until recently, there did not exist a direct way to make the most important component in the coupling reaction, the boronic acid. Current methods to make boronic acids often employ harsh or wasteful reagents to prepare boronic acid derivatives and require addnl. steps to afford the desired boronic acid. The scope of the previously reported Pd-catalyzed, direct boronic acid synthesis is unveiled, which includes a wide array of synthetically useful aryl electrophiles. It makes use of the newly available 2nd generation Buchwald XPhos preformed Pd catalyst and bis-boronic acid. For ease of isolation and to preserve the often sensitive C-B bond, all boronic acids were readily converted to their more stable trifluoroborate counterparts.
Journal of the American Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics