Ohtsuka, Yuhki; Uraguchi, Daisuke; Yamamoto, Kyoko; Tokuhisa, Kenji; Yamakawa, Tetsu published an article on January 31 ,2016. The article was titled 《Fenton reagent-catalyzed trifluoromethylation of enamines of 3-oxocarboxylates with CF3I》, and you may find the article in Journal of Fluorine Chemistry.Safety of Ethyl 3-(4-chlorophenyl)propanoate The information in the text is summarized as follows:
The trifluoromethylation of enamines of Et 3-oxocarboxylates catalyzed by Fenton reagent with CF3I was investigated. Trifluoromethylation followed by acid hydrolysis provided 3-oxo-2-(trifluoromethyl)carboxylates in 64-94% yields, which were greater than those obtained by the trifluoromethylation of 3-oxocarboxylates as reported previously. Enamines trifluoromethylated at the 2-position were isolated as intermediates. Hydrolysis and successive decarboxylation of the obtained 3-oxo-2-(trifluoromethyl)carboxylates under acidic conditions provided (2,2,2-trifluoroethyl)ketones in satisfactory yields. The synthesis of the target compounds was achieved using sulfuric acid iron(2+) salt (i.e., iron sulfate) and hydrogen peroxide (H2O2) as Fenton reagent. Starting materials included (iodo)trifluoromethane and enamines, such as 3-amino-2-butenoic acid ester, 3-amino-4-methyl-2-pentenoic acid ester, 3-amino-2-heptenoic acid ester, 3-amino-3-phenyl-2-propenoic acid ester. The title compounds thus formed included 3-oxo-2-(trifluoromethyl)butanoic acid ester, 4-methyl-3-oxo-2-(trifluoromethyl)pentanoic acid ester, β-oxo-α-(trifluoromethyl)benzenepropanoic acid ester. Hydrolysis products included trifluoromethyl ketones, such as 4,4,4-trifluoro-2-butanone, 1,1,1-trifluoro-4-methyl-3-pentanone, 1,1,1-trifluoro-3-heptanone, 3,3,3-trifluoro-1-phenyl-1-propanone. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Safety of Ethyl 3-(4-chlorophenyl)propanoate)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Safety of Ethyl 3-(4-chlorophenyl)propanoate Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics