Palate, Kleopas Y.; Yang, Zhongzhen; Whitwood, Adrian C.; Unsworth, William P. published the artcile< Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions>, Related Products of 17082-09-6, the main research area is lactam macrocyclic peptide mimetic preparation; primary amine cyclic imide conjugate addition ring expansion.
A novel conjugate addition/ring expansion (CARE) cascade reaction sequence is reported that enables medium-sized ring and macrocyclic bis-lactams to be prepared from primary amines and cyclic imides. The reactions are simple to perform, generally high yielding, and very broad in scope, especially with respect to the primary amine component. CARE reactions can also be performed iteratively, enabling β-peptoid-based macrocyclic peptide mimetics to be ‘grown’ via well controlled, sequential 4-atom ring expansion reactions, with the incorporation of varied functionalized amines during each iteration.
RSC Chemical Biology published new progress about Conjugate addition reaction. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics