Taylor, Steven J.; Soleymanzadeh, Fariba; Eldrup, Anne B.; Farrow, Neil A.; Muegge, Ingo; Kukulka, Alison; Kabcenell, Alisa K.; DeLombaert, Stephane published the artcile< Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase>, COA of Formula: C7H6Cl2O2S, the main research area is nicotinamide derivative preparation soluble epoxide hydrolase inhibitory activity.
A series of potent nicotinamide inhibitors, e.g., I, of soluble epoxides hydrolase (sEH) is disclosed. This series was designed using structure-based deconstruction and a combination of two HTS hit series, resulting in hybrid analogs that retained the optimal potency from one series, and acceptable in vitro metabolic stability from the other. Structure-guided optimization of these analogs gave rise to nanomolar inhibitors of human sEH that had acceptable plasma exposure to qualify them as probes to determine the in vivo phenotypic consequences of sEH inhibition.
Bioorganic & Medicinal Chemistry Letters published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, COA of Formula: C7H6Cl2O2S.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics