Trost, Barry M.; Tracy, Jacob S. published the artcile< Vanadium-Catalyzed Synthesis of Geometrically Defined Acyclic Tri- and Tetrasubstituted Olefins from Propargyl Alcohols>, Quality Control of 128-09-6, the main research area is bromo chloro iodo trisubstituted tetrasubstituted enone diastereoselective preparation; vanadium catalyst stereoselective bromination chlorination iodination propargyl alc; stereoselective bromination chlorination iodination propargyl alc aqueous hexafluoroisopropanol.
Aryl tri- and tetrasubstituted α-halo-α,β-unsaturated ketones and tetrasubstituted β-halo-α,β-unsaturated ketones were prepared diastereoselectively from propargyl alcs. and halonium ion sources using either the vanadium catalyst [(4-ClC6H4)3SiO]3V(:O) (for α-halo unsaturated ketones) or using halonium ion sources with aqueous hexafluoroisopropanol as the solvent via 1,2-aryl shifts (for β-halo unsaturated ketones). In some cases, isomerization of (E)-α-chloro-α,β-unsaturated ketones in the presence of DMAP in DMF yielded the corresponding (Z)-α-chloro-α,β-unsaturated ketones in > 20:1 diastereoselectivities. These methods allow the preparation of stereodefined tri- and tetrasubstituted olefins; the methods were used to prepare various compounds including the sesquiterpene (±)-myodesmone.
ACS Catalysis published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Quality Control of 128-09-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics