Ullah, Safi; Saeed, Muhammad; Ullah, Irfan; Halimi, Syed Muhammad Ashhad; Khan, Khalid Mohammed; Jahan, Saqib; Mohani, Syed Nadeem; Khan, Saifullah; Khan, Ajmal published the artcile< Synthesis and characterization of novel piroxicam derivatives and their antiglycation activity>, Product Details of C7H6Cl2O3S, the main research area is piroxicam derivative preparation SAR antiglycation.
A series of sulfonated esters of piroxicam I (R = Me, Et, Ph, etc.) were synthesized by substitution of “”H”” from hydroxyl “”OH”” group of piroxicam with different alkyl/aryl sulfonyl chloride by continuous stirring at room temperature Compounds I were screened for antiglycation activity, in order to analyze the effect of substitution for the management of late diabetic complications. The preliminary results showed that compound I (R = Ph) exhibited potent antiglycation activity far better than the reference (rutin IC50 = 274.5 ± 0.05μM), while compounds I (R = 2,4-(MeO)2C6H3) and I (R = 4-ClC6H4) were similar with IC50 values of 178.9 ± 1.55μM, 237 ± 2.01μM, and 256.5 ± 2.56μM resp. Moreover a neg. effect of electron withdrawing groups was observed over the inhibition potential of different analogs depending upon the number and the positions of the substituents.
Journal of Molecular Structure published new progress about Advanced glycation end product inhibitors. 22952-32-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O3S, Product Details of C7H6Cl2O3S.
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Chloride – Wikipedia,
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