《Design, synthesis and antibacterial activity evaluation of novel 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide derivatives》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Zarei, Samaneh; Komeili, Golzar; Bahadorikhalili, Saeed; Yahya-Meymandi, Azadeh; Karami-Zarandi, Morteza; Larijani, Bagher; Biglar, Mahmood; Sadat Ebrahimi, Seyed Esmaeil; Mahdavi, Mohammad. Reference of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:
In this paper, a novel series of 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide derivatives I (R = t-Bu, Cy; R1 = 4-F, 2-Me, 4-NO2, etc.; R2 = H, OMe) are synthesized in two steps. The first step involved Ugi multicomponent reaction of β-alanine, o-(propargyl)benzaldehydes 3-R2-4-(HCCCH2O)C6H3CHO and isocyanide derivatives RN+C-. The product of this step, underwent a click 1,3-dipolar cycloaddition reaction with benzyl azide derivatives R1C6H4CH2N3. The 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide products I were characterized and their antibacterial activities were evaluated against various G-pos. (Staphylococcus aureus and Bacillus subtilis) and G-neg. (Pseudomonas aeruginosa and Escherichia coli) bacteria, using minimal inhibition concentration The compounds I showed very good antimicrobial activity and a number of products have been more active than ciprofloxacin. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Reference of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Reference of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics