In 2022,Bai, Junping; Zhou, Junliang; Ji, Xin; Wang, Nannan; Dong, Xiaochun; Wu, Wei; Zhao, Weili published an article in Chinese Chemical Letters. The title of the article was 《Development of environment-insensitive and highly emissive BODIPYs via installation of N,N’-dialkylsubstituted amide at meso position》.Computed Properties of C3H3ClO3 The author mentioned the following in the article:
Fluorescent dyes play a crucial role in fluorescence imaging and sensing technol. However, there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane permeability. Fluorescent dyes with strong fluorescence emission in both nonpolar and polar solvents are highly desirable. In this manuscript, we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N’-dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Computed Properties of C3H3ClO3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C3H3ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics