Safety of (3-Fluorophenyl)boronic acidIn 2021 ,《Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit》 appeared in RSC Medicinal Chemistry. The author of the article were Barbaro, Lisa; Nagalingam, Gayathri; Triccas, James A.; Tan, Lendl; West, Nicholas P.; Baell, Jonathan B.; Priebbenow, Daniel L.. The article conveys some information:
Despite promising efficacy, the clin. use of the anti-tubercular therapeutic bedaquiline has been restricted due to safety concerns. To date, limited SAR studies have focused on the quinoline ring (A-ring), and as such, we set out to explore modifications within this region in an attempt to discover new bedaquiline variants with an improved safety profile. We herein report the development of unique synthetic strategies that facilitated access to novel bedaquiline analogs leading to the discovery that anti-tubercular activity could be retained following replacement of the quinoline motif with pyridine heterocycles. This discovery is anticipated to open up multiple new avenues for exploration in the design of improved anti-tubercular therapeutics. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Safety of (3-Fluorophenyl)boronic acid)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Safety of (3-Fluorophenyl)boronic acid
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