Formula: C11H13ClO2On March 31, 2008, Bohman, B.; Nordlander, G.; Nordenhem, H.; Sunnerheim, K.; Borg-Karlson, A.-K.; Unelius, C. R. published an article in Journal of Chemical Ecology. The article was 《Structure-Activity Relationships of Phenylpropanoids as Antifeedants for the Pine Weevil Hylobius abietis》. The article mentions the following:
Et cinnamate has been isolated from the bark of Pinus contorta in the search for antifeedants for the pine weevil, Hylobius abietis. Based on this lead compound, a number of structurally related compounds were synthesized and tested. The usability of the Topliss scheme, a flow diagram previously used in numerous structure-activity relationship (SAR) studies, was evaluated in an attempt to find the most potent antifeedants. The scheme was initially followed stepwise; subsequently, all compounds found in the scheme were compared. In total, 51 phenylpropanoids were tested and analyzed for SARs by using arguments from the field of medicinal chem. (rational drug design). Individual Hansch parameters based on hydrophobicity, steric, and electronic properties were examined The effects of position and numbers of substituents on the aromatic ring, the effects of conjugation in the mols., and the effects of the properties of the parent alc. part of the esters were also evaluated. It proved difficult to find strong SARs derived from single physicochem. descriptors, but our study led to numerous new, potent, phenylpropanoid antifeedants for the pine weevil. Among the most potent were Me 3-phenylpropanoates monosubstituted with chloro, fluoro, or Me groups and the 3,4-dichlorinated Me 3-phenylpropanoate. After reading the article, we found that the author used Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Formula: C11H13ClO2)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Formula: C11H13ClO2 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics