Chen, Ying; Sheng, Daopeng; Wang, Fei; Rao, Weidong; Shen, Shu-Su; Wang, Shun-Yi published an article in 2022. The article was titled 《Nickel(II)/TPMPP catalyzed reductive coupling of oxalates and tetrasulfides: synthesis of unsymmetric disulfides》, and you may find the article in Organic Chemistry Frontiers.Application In Synthesis of Methyl 2-chloro-2-oxoacetate The information in the text is summarized as follows:
A Ni(II)/tris(para-methoxyphenyl)phosphine (TPMPP)-catalyzed reductive cross-coupling reaction of benzyl oxalates and tetrasulfides to synthesize unsym. disulfides was reported. The benzyl oxalate works as the carbon radical precursor in this reaction. This catalytic strategy has the advantages of mild reaction conditions, wide substrate range and easy operation and provided a new approach for the preparation of unsym. disulfides with good functional group tolerance. Also, this method successfully achieved the synthesis of disulfides at the gram-scale, making it highly valuable. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Application In Synthesis of Methyl 2-chloro-2-oxoacetate)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application In Synthesis of Methyl 2-chloro-2-oxoacetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics