The author of 《Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles》 were Guo, Yingying; Wang, Zhoulu; Zhu, Ying; Zhang, Qiaochu; Wei, Donghui; Liu, Xiang; Fu, Zhenqian. And the article was published in Organic Chemistry Frontiers in 2019. SDS of cas: 5781-53-3 The author mentioned the following in the article:
An efficient and direct strategy for the synthesis of polyfunctionalized carbazoles I [R1 = H, 2-Me, 3-Cl, etc.; R2 = Me, Et, Bn, etc.; R3 = H, 8-OMe, 9,10-di-Br; X = NTs, NSO2Ph, O, S] and II [R4 = H, 2-Me, 3-Cl, 2-NO2; R5 = OMe, OEt, OBn; X = NTs, NSO2Ph, S] was developed via formal [4 + 2] annulation of 2-methyl-3-oxoacetate indoles with naphthalene-1,4-dione or dialkyl acetylene dicarboxylate in acceptable to excellent yields. This reaction featured H2O as the only byproduct, broad substrate scope and proceeded under mild conditions. In addition to this study using Methyl 2-chloro-2-oxoacetate, there are many other studies that have used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3SDS of cas: 5781-53-3) was used in this study.
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics