Katsura, Yousuke; Aratani, Matsuhiko published their research in Tetrahedron Letters on December 19 ,1994. The article was titled 《A convenient protective method for the 7-amino function on a cephem derivative in Wittig vinylation》.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride The article contains the following contents:
A novel preparative pathway for diphenylmethyl 7β-amino-3-vinylceph-3-em-4-carboxylate from 3-chloromethyl derivative is described. As a convenient protecting group for the 7-amino function in a Wittig reaction, six membered azine derivatives, e.g., I, incorporating the 7-amino group were developed as a surrogate of conventional protecting groups. The experimental process involved the reaction of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)
(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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Chloride – Wikipedia,
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