Quality Control of 3-ChlorobenzylchlorideOn September 30, 2019 ,《New potent antifungal triazole alcohols containing N-benzylpiperazine carbodithioate moiety: Synthesis, in vitro evaluation and in silico study》 was published in Bioorganic Chemistry. The article was written by Mahmoudi, Yaser; Badali, Hamid; Hashemi, Seyedeh Mahdieh; Ansari, Mahsa; Fakhim, Hamed; Fallah, Marjan; Shokrzadeh, Mohammad; Emami, Saeed. The article contains the following contents:
A number of 1H-1,2,4-triazole alcs. containing N-(halobenzyl)piperazine carbodithioate moiety were designed and synthesized as potent antifungal agents. In vitro bioassays against different Candida species including C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis revealed that the N-(4-chlorobenzyl) derivative(I) with MIC values of 0.063-0.5μg/mL had the best profile of activity, being 4-32-fold more potent than fluconazole. Docking simulation studies confirmed the better fitting of I deriv in the active site of lanosterol 14α-demethylase (CYP51) enzyme, the main target of azole antifungals. Particularly, the potential of I against fluconazole-resistant isolates along with its minimal toxicity against human erythrocytes and HepG2 cells make this prototype compound as a good lead for discovery of potent and safe antifungal agents. The experimental process involved the reaction of 3-Chlorobenzylchloride(cas: 620-20-2Quality Control of 3-Chlorobenzylchloride)
3-Chlorobenzylchloride(cas: 620-20-2) has been used in the reaction of 3-methoxybenzyl chloride and ethyl 4-bromobenzoate in pure water, using zinc dust and a Pd catalyst.Quality Control of 3-Chlorobenzylchloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics