《Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds》 was written by Naito, Takayuki; Aburaki, Shimpei; Kamachi, Hajime; Narita, Yukio; Okumura, Jun; Kawaguchi, Hiroshi. Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride And the article was included in Journal of Antibiotics on August 31 ,1986. The article conveys some information:
Cephems, e.g., I (R = Me, Et, CHMe2, CH2CH:CH2, CH2CCH), were prepared and the structure-activity relationship of various substituents on the oxyimino moiety and on the quaternary ammonium moiety was determined I (R = Me) had broad antimicrobial activity against Gram-pos. and Gram-neg. bacteria, including Pseudomonas aeruginosa. The experimental part of the paper was very detailed, including the reaction process of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride)
(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics