Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochlorideOn September 30, 1995 ,《Studies on 3′-quaternary ammonium cephalosporins II. Synthesis and antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]cephalosporin derivatives bearing various quaternary ammonium methyl groups at the 3 position》 was published in Journal of Antibiotics. The article was written by Ohki, Hidenori; Kawabata, Kohji; Okuda, Shinya; Kamimura, Toshiaki; Sakane, Kazuo. The article contains the following contents:
Synthesis and antibacterial activity of quaternary ammonium cephalosporins is reported. Extremely potent broad-spectrum activity against both Gram-pos. bacteria, including S. aureus, and Gram-neg. bacteria, including P. aeruginosa, is exhibited by 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(3-amino-2-methylpyrazolio)-methyl-3-cephem-4-carboxylate.(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride) was used in this study.
(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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