In 2022,Sun, Bin; Tian, Hai-Xia; Ni, Zhi-Gang; Huang, Pan-Yi; Ding, Hao; Li, Bing-Qian; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu published an article in Organic Chemistry Frontiers. The title of the article was 《Photocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light》.Reference of Thiophene-2-sulfonyl chloride The author mentioned the following in the article:
Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics