Category: chlorides-buliding-blocksIn 2020 ,《The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions》 was published in Organic Chemistry Frontiers. The article was written by Xu, Jia; Yang, Zhao; Hua, Jiawei; Lin, Yang; Bian, Mixue; Li, Yuguang; Liu, Chengkou; He, Wei; Fang, Zheng; Guo, Kai. The article contains the following contents:
An efficient and green electrochem. continuous-flow approach was developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones I [R1 = H, 8-Fe, 5,7-di-Me, etc.; R2 = Me, Et, Ph, etc.; R3 = Me, Ph, 2-thienyl, etc.] through the sulfonylation of alkenes with sulfonylhydrazides. The reaction proceeded in a continuous-flow electrolytic cell under metal-free and oxidant-free conditions. A series of activated alkenes were suitable for this system, and the corresponding products I were obtained in moderate to good yields. Moreover, reaction scale-up was smoothly achieved using the electrochem. continuous-flow system without changing the reaction conditions. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics