《Efficient One-Pot Multifunctionalization of Alkynes en Route to α-Alkoxyketones, α-Thioketones, and α-Thio Thioketals by using an Umpolung Strategy》 was published in Chemistry – A European Journal in 2017. These research results belong to Xu, Zhou; Zhai, Rongliang; Liang, Ting; Zhang, Liming. Product Details of 39183-20-5 The article mentions the following:
The use of polarized synthons is a highly desirable strategy, as it generally enables unprecedented retrosynthetic disconnections for the synthesis of unique substances. Herein, a new approach for α-alkoxy and α-alkylthio ketones R1C(O)CH2XR2 [X = O, S; R1 = n-nonyl, R2 = Me, i-Pr, H2C:CHCH2, cyclohexyl, etc.; R1 = Cl(CH2)3, HO(CH2)4, (EtO2C)2CH, etc., R2 = Et] and α-thio thioketals R1C(SR2)2CH2SR2 (R1 = n-Bu, 2-phthalimidoethyl, PhOCH2CH2, etc.; R2 = Et, n-Pr, i-Pr) via an intermol. umpolung reaction between nucleophiles, such as alcs. or thiols R2XH and N-alkenyloxypyridinium salts H2C:CR1OPy+ -NTf2 (Py+ = 1-pyridinium), which were generated from the corresponding alkynes R1CCH, has been developed for the first time. The reactions proceed with good substrate scope and excellent functional group tolerance in one-pot manner. Applications of the products, α-oxygenated ketones, to the synthesis of other valuable synthetic moieties have also been successfully achieved.2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5Product Details of 39183-20-5) was used in this study.
2-Methyl-5-nitro-6-chlorophenol(cas: 39183-20-5) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 39183-20-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics