Yagishita, Fumitoshi; Okamoto, Kazuma; Kamataki, Norifumi; Kanno, Shota; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published their research in Chemistry Letters on December 5 ,2013. The article was titled 《Chiral symmetry breaking of axially chiral nicotinamide by crystallization from the melt》.Product Details of 66662-48-4 The article contains the following contents:
One of six 2-alkylamino-4,6-dimethylnicotinamides afforded a conglomerate, and subsequent X-ray crystallog. anal. revealed that the compound crystallized in the monoclinic system, the space group P21. Crystallization of the racemic nicotinamide from the melt led to the chiral breaking of symmetry from 83 to 92% ee. This amide exhibited considerably stable axial chirality (δG ‡ 22.4-23.5 kcal mol-1 at 20 °) due to rotationally restricted scaffolds for the C-C(=O) bond. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Product Details of 66662-48-4)
2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 66662-48-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics