Yamanaka, Hideaki; Chiba, Toshiyuki; Kawabata, Kohji; Takasugi, Hisashi; Masugi, Takashi; Takaya, Takao published their research in Journal of Antibiotics on December 31 ,1985. The article was titled 《Studies on β-lactam antibiotics. IX. Synthesis and biological activity of new orally active cephalosporin, cefixime (FK027)》.Recommanded Product: 79349-53-4 The article contains the following contents:
7β-[(Z)-2-(2-Amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]-3- vinyl-3-cephem-4-carboxylic acid (I) was prepared from diphenylmethyl 7-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride (II), prepared from 7-aminocephalosporanic acid by two parallel routes differing primarily in the protection of the 7-amino group. II was alternatively prepared from deacetylcephalosporin C sodium salt with improved yields. Two pathways for the conversion of II to I are provided. I is orally active with a widely expanded antimicrobial activity and high stability to β-lactamases. In the experiment, the researchers used many compounds, for example, (6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Recommanded Product: 79349-53-4)
(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 79349-53-4 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics