In 2019,Organic Chemistry Frontiers included an article by Zhang, Huiru; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan; Jin, Liqun. Formula: C7H6BrCl. The article was titled 《Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides》. The information in the text is summarized as follows:
A facile Cu-catalyzed benzylation of terminal alkynes RCCH (R = Ph, thiophen-3-yl, cyclopropyl, n-C6H13, etc.) from easily available benzyl bromides R1CH(R2)Br (R1 = Ph, thiophen-2-yl, naphthalen-2-yl, etc.; R2 = H, Me, Et) and 1-(phenylethynyl)-indane, 1-(phenylethynyl)-1,2,3,4-tetrahydronaphthalene, 4-(phenylethynyl)chroman have been developed. Both primary and secondary benzylic bromides have been successfully coupled with various aryl alkynes, alkyl alkynes and enynes, selectively affording benzyl alkynes RCCCH(R2)R1 in moderate to excellent yields. Examples of scale-up reactions as well as the application for preparing substituted allenes as 1,3-diphenylpropa-1,2-diene, 1,3-diphenyl-buta-1,2-diene and 9-benzyl-10-methylphenanthrene have further demonstrated the practicality and efficiency of the developed strategy. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics