Ban, Tao; Vu, Huu-Manh; Zhang, Jing; Yong, Jia-Yuan; Liu, Qiong; Li, Xu-Qin published the artcile< Rhodium-Catalyzed Azine-Directed C-H Amidation with N-Methoxyamides>, Category: chlorides-buliding-blocks, the main research area is hydrazinylidene amide preparation; azine methoxyamide amidation rhodium catalyst.
Using N-methoxyamide reagents R1C(O)NHOCH3 (R1 = Ph, cyclohexyl, naphth-1-yl, thiophen-2-yl, etc.) as an amide source, C-H amidation was realized at the ortho position of azine under the action of rhodium and boric acid. The method has mild reaction conditions, high at. utilization, excellent yield, and wide adaptability to amidation reagents (both aromatic amides and fatty amides are applicable). Amide-substituted ketones can be obtained by a simple treatment and further transformed into bioactive substances. This provides a good supplement for the C-H bond amidation of aromatic rings.
Journal of Organic Chemistry published new progress about Amidation. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics