Borsoi, Ana Flavia; Paz, Josiane Delgado; Pissinate, Kenia; Rambo, Raoni Scheibler; Pestana, Victor Zajaczkowski; Bizarro, Cristiano Valim; Basso, Luiz Augusto; Machado, Pablo published their research in Molecules in 2021. The article was titled 《Ultrasound-assisted synthesis of 4-alkoxy-2-methylquinolines: an efficient method toward antitubercular drug candidates》.Formula: C7H6BrCl The article contains the following contents:
Herein, a new synthetic approach was established providing efficient and rapid access (15 min) to a series of 4-alkoxy-6-methoxy-2-methylquinolines I (R = 4-nitrophenyl, 3,4-difluorophenyl, naphthalen-2-yl, etc.) using ultrasound energy. The new synthetic protocol provides a simple procedure utilizing an open vessel system that affords the target products I at satisfactory yields (45-84%) and elevated purities (≳95%). The methodol. allows the evaluation of a larger number of mols. in assays against the bacillus, facilitating the determination of the structure-activity relationship with a reduced environmental cost. The results came from multiple reactions, including the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics