Chen, Ping; Wang, Kai; Zhang, Boyu; Guo, Wengang; Liu, Yan; Li, Can published the artcile< Water enables an asymmetric cross reaction of α-keto acids with α-keto esters for the synthesis of quaternary isotetronic acids>, Application of C8H8BrCl, the main research area is quaternary isotetronic acid preparation chemoselective enantioselective; keto acid ester tandem cross coupling pyrrolidinyl imidazole catalyst.
A water promoted asym. aldol/lactonization/enolization cascade reaction of α-keto acids R1CH2C(O)C(O)OH (R1 = H, Me) and α-keto esters R2C(O)C(O)OC(CH3)3 [R2 = 4-FC6H4(CH2)2, CH2=CH(CH2)2, C6H5CH2O(CH2)3, etc.] was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids I with excellent enantioselectivity. Theor. results indicate that intramol. ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity.
Chemical Communications (Cambridge, United Kingdom) published new progress about Cross-coupling reaction catalysts, stereoselective (regioselective). 16799-05-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H8BrCl, Application of C8H8BrCl.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics