《Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol》 was written by Chen, Yi-Xuan; Wang, Zhu-Jun; Xiao, Jun-An; Chen, Kai; Xiang, Hao-Yue; Yang, Hua. Computed Properties of C4H3ClO2S2This research focused ontrifluoromethyl sulfonyl tertiary alc preparation; sodium sulfinate trifluoromethylstyrene sulfonation. The article conveys some information:
Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcs. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant mols. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics