Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R. published the artcile< Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4>, Related Products of 42413-03-6, the main research area is homopiperazinylsulfonamide preparation structure activity relationship pharmacokinetics mGlu4 modulator; pos allosteric modulator mGlu4 homopiperazinylsulfonamide preparation amidation sulfonamidation; sulfonyl chloride amine reactant homopiperazinylsulfonamide preparation.
Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of pos. allosteric modulators for mGlu4, a G-protein coupled receptor. This series is comprised of a homopiperazine central core, e.g. I and II. The solution-phase parallel synthesis and SAR of analogs derived from this series will be presented. This series of pos. allosteric modulators of mGlu4 provide critical research tools to further probe the mGlu4-mediated effects in Parkinson’s disease.
ACS Combinatorial Science published new progress about Amidation. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Related Products of 42413-03-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics