Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia; Liu, Jingchun; Middleton, Steven A. published the artcile< (Phenylpiperidinyl)cyclohexylsulfonamides: Development of α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)>, HPLC of Formula: 351003-34-4, the main research area is phenylpiperidinylcyclohexyl benzenesulfonamide preparation alpha1a alpha1d selective adrenergic receptor antagonist; benign prostatic hyperplasia lower urinary tract drug phenylpiperidinylcyclohexyl benzenesulfonamide.
Although α1 adrenergic receptor blockers can be very effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), their usage is limited by CV-related side-effects that are caused by the subtype non-selective nature of the current drugs. To overcome this problem, it was hypothesized that a α1a/1d subtype selective antagonist would bring more benefit for the therapy of BPH/LUTS. In developing such selective α1a/1d ligands, (phenylpiperidinyl)cyclohexylsulfonamides (e.g. N-[cis-4-[4-(2-isopropoxyphenyl)piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide) were synthesized and evaluated for binding to three cloned human α1-adrenergic receptor subtypes. Many compounds showed equal affinity for both α1a and α1d subtypes with good selectivity vs. the α1b subtype.
Bioorganic & Medicinal Chemistry Letters published new progress about Arenesulfonamides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 351003-34-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H5ClF2O3S, HPLC of Formula: 351003-34-4.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics