Clardy, J. C.; Mosbo, J. A.; Verkade, J. G. published the artcile< Crystal and molecular structure of the carcinostat cyclophosphamide hydrate>, Recommanded Product: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is cyclophosphamide structure.
The structure of 2-oxo-2-[bis(β-chloroethyl)amino]-1-hydro-1,3,2-azaoxaphosphorinane (cyclophosphamide), determined by x-ray diffraction, shows that the phosphoryl O is axial and the amino moiety equatorial. The sum of the angles around the exocyclic N is 360.1 ± 0.6.degree. and the plane defined by the atoms attached to this N very nearly bisects the NPO angle of the ring. A water mol. forms H bonds to 2 cyclophosphamide mols. via the phosphoryl O and the proton on the ring N. The triclinic crystals belong to the space group P with Z = 2. The unit-cell parameters are a 8.65(1), b 13.39(1), c 6.01(1) Å, α 96.3(1).degree., β 100.3(1).degree., and γ 106.7(1).degree.. The final R and ωR factors are 0.072 and 0.092 for the 1601 observed reflections, resp.
Phosphorus and the Related Group V Elements published new progress about Crystal structure. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Recommanded Product: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics