In 2019,ChemistrySelect included an article by Dandia, Anshu; Saini, Pratibha; Bansal, Sarika; Parewa, Vijay. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《One-Pot Copper(I)-Catalyzed Synthesis of 2-Aryl-quinazolin-4(3H)-ones via N-benzylation/Csp3-H Oxidation/CN Hydrolysis/Cyclization》. The information in the text is summarized as follows:
A Cu(I)-catalyzed straightforward synthesis of quinazolin-4(3H)-ones was attained by the reaction of 2-aminobenzonitrile with benzyl bromides. The reaction proceeded via one pot N-benzylation/CSp3- H oxidation/CN hydrolysis/cyclization sequence. Numerous controlled experiments were carried out to establish the appropriate mechanism and prerequisite of the reactions. The process was truly selective as only quinazolinones formed as desired product over dihydrogenated quinazolinones. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics