Quality Control of 3-Chloro-4-fluoronitrobenzeneOn September 16, 2021 ,《Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents》 was published in ChemMedChem. The article was written by Fujii, Shinya; Kikuchi, Eriko; Suzuyama, Honoka; Watanabe, Yuko; Ishigami-Yuasa, Mari; Masuno, Hiroyuki; Mori, Takayasu; Isobe, Kiyoshi; Uchida, Shinichi; Kagechika, Hiroyuki. The article contains the following contents:
Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative I, and the veterinary anthelmintic closantel (II) led to the discovery of compound III as a potent SPAK inhibitor with reduced toxicity. Compound III decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs. The results came from multiple reactions, including the reaction of 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Quality Control of 3-Chloro-4-fluoronitrobenzene)
3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 3-Chloro-4-fluoronitrobenzene Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics