In 2022,Hou, Liting; Huang, Wenyi; Wu, Xianqing; Qu, Jingping; Chen, Yifeng published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed Carbonylation of Cyclopropanol with Benzyl Bromide for Multisubstituted Cyclopentenone Synthesis》.Category: chlorides-buliding-blocks The author mentioned the following in the article:
Herein, the authors report a Ni-catalyzed carbonylation of cyclopropanol with benzyl bromide to afford multisubstituted cyclopentenone under 1 atm of CO. The reaction proceeds through a cascade carbonylation of benzyl bromides, followed by generation of nickel homoenolate from cyclopropanols via β-C elimination to afford 1,4-diketones, which undergoes intramol. aldol condensation to furnish highly substituted cyclopentenone derivatives I [Ar = Ph, R = Ph, 4-MeOC6H4, 3-ClC6H4, etc.; Ar = 2-naphthyl, 3-MeOC6H4, 4-ClC6H4, etc., R = Ph] in moderate to good yields. The reaction exhibited high functional group tolerance with broad substrate scope. After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics