《Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4′-pyridyl)carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors》 was written by Huang, Boshi; Gunta, Rama; Wang, Huiqun; Li, Mengchu; Cao, Danni; Mendez, Rolando E.; Gillespie, James C.; Chen, Chongguang; Huang, Lan-Hsuan M.; Liu-Chen, Lee-Yuan; Selley, Dana E.; Zhang, Yan. Safety of 2-Chloroisonicotinic acid And the article was included in Bioorganic Chemistry on April 30 ,2021. The article conveys some information:
In the present study, the role of 3-hydroxy group of a series of epoxymorphinan derivatives I (R1 = H, OH; R2 = Cl, Br, CN, Me, OMe) in their binding affinity and selectivity profiles toward the opioid receptors (ORs) has been investigated. It was found that the 3-hydroxy group was crucial for the binding affinity of these derivatives for all three ORs due to the fact that all the analogs I (R1 = OH) exhibited significantly higher binding affinities compared to their counterpart 3-dehydroxy ones I (R1 = H). Meanwhile most compounds carrying the 3-hydroxy group possessed similar selectivity profiles for the kappa opioid receptor over the mu opioid receptor as their corresponding 3-dehydroxy derivatives The [35S]-GTPγS functional assay results indicated that the 3-hydroxy group of these epoxymorphinan derivatives I was important for maintaining their potency on the ORs with various effects. Further mol. modeling studies helped comprehend the remarkably different binding affinity and functional profiles between compound I (R1 = H, R2 = CN)(NCP) and its 3-dehydroxy analog I (R1 = OH, R2 = CN). The experimental process involved the reaction of 2-Chloroisonicotinic acid(cas: 6313-54-8Safety of 2-Chloroisonicotinic acid)
2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Safety of 2-Chloroisonicotinic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics