Jatav, Varsha; Mishra, Pradeep; Kashaw, Sushil; Stables, J. P. published the artcile< Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is thiadiazolylstyryl quinazolinone preparation anticonvulsant sedative hypnotic CNS depressant agent.
A series of novel 3-[5-substituted phenyl-1,3,4-thiadiazol-2-yl]-2-styryl quinazoline-4(3H)-ones were synthesized and evaluated for anticonvulsant, sedative-hypnotic and CNS depressant activities. After i.p. injection to mice at doses of 30, 100, and 300 mg/kg body weight 2-styrylquinazolin-4(3H)-one derivatives were examined in the maximal electroshock induced seizures (MES) and s.c. pentylenetetrazole (scPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. Out of eighteen compounds only five, e.g., I (R = H or Cl), showed anticonvulsant activity in one or more test models. All except two compounds exhibited significant sedative-hypnotic activity via actophotometer screen. CNS depressant activity screened with the help of the forced swim pool method resulted into some potent compounds From the exptl. observation it can be concluded that synthesized compounds exhibited relatively better sedative-hypnotic and CNS depressant activities.
European Journal of Medicinal Chemistry published new progress about Anticonvulsants. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.
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