In 2003,Organic Syntheses included an article by Jensen, Anne Eeg; Kneisel, Florian; Knochel, Paul. Product Details of 7116-36-1. The article was titled 《Ethyl 3-(p-cyanophenyl)propionate from ethyl 3-iodopropionate and p-cyanophenylzinc bromide》. The information in the text is summarized as follows:
The reaction of bromo(4-cyanophenyl)zinc with 3-iodopropanoic acid Et ester in the presence of bis(acetylacetonato)nickel and 4-fluorostyrene gave the title compound, 4-cyanobenzenepropanoic acid Et ester. The role of 4-fluorostyrene is to reduce the electron d. of an [(aryl)nickel(alkyl)] intermediate by coordinating the nickel center and consequently favoring a reductive elimination leading to an aryl-alkyl product. The reaction represents a cross-coupling between an aryl organometallic reactant and an alkyl iodide derivative The nickel-catalyzed cross-coupling of other arylzinc bromides with alkyl iodides in the presence of 4-(trifluoromethyl)styrene was also reported. Arylzinc bromides can be prepared from aryllithium or arylmagnesium precursors. The experimental process involved the reaction of Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Product Details of 7116-36-1)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Product Details of 7116-36-1 Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics