《CuCl2-promoted decomposition of sulfonyl hydrazides for the synthesis of thiosulfonates》 was written by Kim, Junsu; Park, Sanggil; Kim, Hyungjun; Kim, Jinho. Application In Synthesis of 4-Chlorobenzenesulfonyl chlorideThis research focused onthiosulfonate preparation copper catalyst; sulfonyl hydrazide decomposition. The article conveys some information:
Sulfonyl hydrazides recently received much attention as reagents for the introduction of sulfur-containing functional groups into organic compounds, because both sulfonyl and sulfenyl sources could be generated by the oxidation and decomposition of the sulfonyl hydrazides, resp. However, the transformations of sulfonyl hydrazides into thiosulfonates, which could be produced by the reaction between sulfonyl and sulfenyl sources, have been less investigated. In this manuscript, CuCl2-promoted selective synthesis of thiosulfonates I (R = 4-Me, 4-NO2, 3-Br, 2-Naph, etc.) from sulfonyl hydrazides is described. A variety of thiosulfonates were produced in moderate to good yields. The mechanism involving radical intermediates such as sulfonyl radical and thiyl radical was proposed on the basis of the previously reported references and mechanistic investigations. In addition, quantum chem. simulations revealed that Cu-promoted decomposition of sulfonyl hydrazides is thermodynamically viable in the developed conditions. In addition to this study using 4-Chlorobenzenesulfonyl chloride, there are many other studies that have used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application In Synthesis of 4-Chlorobenzenesulfonyl chloride) was used in this study.
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Application In Synthesis of 4-Chlorobenzenesulfonyl chloride The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics