Liu, Jianbo; Parker, Matthew F. L.; Wang, Sinan; Flavell, Robert R.; Toste, F. Dean; Wilson, David M. published their research in Chem on August 12 ,2021. The article was titled 《Synthesis of N-trifluoromethyl amides from carboxylic acids》.Computed Properties of C6H4ClNO2 The article contains the following contents:
Here, the synthesis of N-trifluoromethyl amides R1C(O)NCF3(R2) [R1 = Et, cyclohexyl, CH2CH2Ph, etc.; R2 = Me, allyl, CH2CH2Ph, etc.] from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature was reported. Through this strategy, isothiocyanates were desulfurized with AgF, and then the formed derivative was acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method showed broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners and should find application in the modification of advanced intermediates. After reading the article, we found that the author used 2-Chloroisonicotinic acid(cas: 6313-54-8Computed Properties of C6H4ClNO2)
2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C6H4ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics