Liu, Renbo; Deng, Xiangping; Peng, Yijiao; Feng, Wanshi; Xiong, Runde; Zou, Yang; Lei, Xiaoyong; Zheng, Xing; Xie, Zhizhong; Tang, Guotao published the artcile< Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents>, Related Products of 22717-55-1, the main research area is flavonoid antitumor microtubules HIF1 alpha glycolysis VEGF gastric cancer; Anti-tumor; Flavonoid; Glycolysis; HIF-1α; Microtubules.
5,6,7-Trimethoxy flavonoid salicylate derivatives were designed by the joining of three important pharmacophores (TMP, flavonoid, and SA) according to the combination principle. A series of novel trimethoxy flavonoid salicylate derivatives were synthesized and their in vitro anti-tumor activities were evaluated. Among these derivatives, compound 7f exhibited excellent antiproliferative activity against HGC-27 cells and MGC-803 cells with IC50 values of 10.26 ± 6.94 μM and 17.17 ± 3.03 μM, resp. Subsequently, the effects on cell colony formation (clonogenic survival assay), cell migration (wound healing assay), cell cycle distribution (PI staining assay), cell apoptosis (Hoechst 33258 staining assay and annexin V-FITC/PI dual staining assay), lactate level (lactate measurement), microtubules disarrangement (immunofluorescence staining anal.) and docking posture (mol. docking simulation) were determined Further western blot anal. confirmed that compound 7f could effectively down-regulate the expression of glycolysis-related proteins HIF-1α, PFKM and PKM2 and tumor angiogenesis-related proteins VEGF. Overall, these studies suggested that compound 7f, as the representative compound of those, might be a promising candidate for the treatment of gastric cancer and deserved the further studies.
Bioorganic Chemistry published new progress about Antitumor agents. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Related Products of 22717-55-1.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics