Lorenz, Daniel A.; Kaur, Tanpreet; Kerk, Samuel A.; Gallagher, Erin E.; Sandoval, Jorge; Garner, Amanda L. published the artcile< Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction>, Electric Literature of 42413-03-6, the main research area is catalytic enzyme linked click chem assay catELCCA.
Dysregulation of microRNA (miRNA) expression has been linked to many human diseases; however, because of the challenges associated with RNA-targeted drug discovery, addnl. approaches are needed for probing miRNA biol. The emerging regulatory role of miRNA-binding proteins in miRNA maturation presents such an alternative strategy. Exploiting our laboratory’s click chem.-based high-throughput screening (HTS) technol., catalytic enzyme-linked click chem. assay or cat-ELCCA, we have designed a modular method by which to discover new chem. tools for manipulating pre-miRNA-miRNA-binding protein interactions. Using the pre-let-7d-Lin28 interaction as proof-of-concept, the results presented demonstrate how HTS using cat-ELCCA can enable the discovery of small mols. targeting RNA-protein interactions.
ACS Medicinal Chemistry Letters published new progress about Bioassay. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Electric Literature of 42413-03-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics