Synthetic Route of ClNaIn 2019 ,《Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells》 was published in Cell Reports. The article was written by Luo, Yang; Xue, Youqiu; Wang, Julie; Dang, Junlong; Fang, Qiannan; Huang, Gonghua; Olsen, Nancy; Zheng, Song Guo. The article contains the following contents:
High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide addnl. evidence that iTreg may have different biol. features from tTreg and suggest a greater potential for clin. utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered. The experimental process involved the reaction of Sodium chloride(cas: 7647-14-5Synthetic Route of ClNa)
Sodium chloride(cas: 7647-14-5) has been used for the preparation of tris buffered saline, phosphate buffered saline, MPM-2 (mitotic protein monoclonal 2) cell lysis buffer, immunoprecipitation wash buffer, LB (Luria-Bertani) media and dialysis buffer.Synthetic Route of ClNa
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics