《Synthesis and biological evaluation of imidazo[2,1-b]thiazole based sulfonyl piperazines as novel carbonic anhydrase II inhibitors》 was written by Manasa, Kesari Lakshmi; Pujitha, Sravya; Sethi, Aaftaab; Arifuddin, Mohammed; Alvala, Mallika; Angeli, Andrea; Supuran, Claudiu T.. Application of 98-60-2 And the article was included in Metabolites in 2020. The article conveys some information:
A novel series of imidazo[2,1-b]thiazole-sulfonyl piperazine conjugates I [R = H, 4-Me, 4-F, 4-MeO, 4-Cl; R1 = H, 4-Me, 4-MeO, 4-Cl, 4-(CH3)3C] synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isoenzyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII, taking acetazolamide (AAZ) as standard drug, using a stopped flow CO2 hydrase assay. The results revealed that most of the compounds showed selective activity against hCA II whereas none of them were active against hCA I, IX, XII (Ki > 100μM). The physiol. dominant cytosolic isoform hCA II was inhibited by these mols. with inhibition constants in the range of 57.7-98.2μM. This new derivative I, thus, selectively inhibited hCA II over the hCA I, IX, XII isoforms, which may be used for further understanding the physiol. roles of some of these isoforms in various pathologies. The results came from multiple reactions, including the reaction of 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Application of 98-60-2)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 98-60-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics