Martins, Solange C.; Desoti, Vania C.; Lazarin-Bidoia, Danielle; Vandresen, Fabio; da Silva, Cleuza C.; Ueda-Nakamura, Tania; Silva, Sueli de O.; Nakamura, Celso V. published the artcile< Synthesis and evaluation of the trypanocidal activity of a series of 1,3,4-thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones>, Related Products of 70057-67-9, the main research area is thiadiazole preparation trypanocidal cytotoxicity.
A series of 1,3,4-thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones I has been synthesized. The synthesized compounds and a series of 1,3,4-thiadiazole without the monoterpene R-(+)-limonene II were tested in in-vitro assays against epimastigote and trypomastigote forms of T. cruzi, and the cytotoxicity was also determined in LLCMK2 cells. The 1,3,4-thiadiazole compounds showed significant trypanocidal activity and a high selectivity indexes. The vast majority of the monoterpene derivatives, substituted by R-(+)-limonene, presented better anti-T. cruzi activity than the non-substituted compounds Regarding the cytotoxic profile, the compounds without the monoterpene R-(+)-limonene were, in general, less toxic. The present findings indicate that the 1,3,4-thiadiazoles derivatives of R-limonene have potential trypanocidal activity that justify further studies to better understand the mechanism of action of these substances on T. cruzi.
Medicinal Chemistry Research published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Related Products of 70057-67-9.
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