Molander, Gary A.; Wisniewski, Steven R. published the artcile< Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates>, Formula: C6H3ClF2, the main research area is aldehyde copper diboration benzylation alkoxylation acylation; potassium acyloxy alkoxyalkyltrifluoroborate preparation palladium arylchloride heteroarylchloride Suzuki Miyaura; aryl acyloxy alkoxy secondary alc stereospecific preparation; stereospecific retention Suzuki Miyaura catalyst palladium preparation.
Potassium 1-(alkoxy/acyloxy)alkyltrifluoroborates have been synthesized through a copper-catalyzed diboration of aldehydes and subsequent conversion of the resulting potassium 1-(hydroxy)alkyltrifluoroborates. The palladium-catalyzed Suzuki-Miyaura reaction employing the potassium 1-(benzyloxy)alkyltrifluoroborates with aryl and heteroaryl chlorides provides access to protected secondary alcs. in high yields. The β-hydride elimination pathway is avoided through use of the benzyl protecting group, which is proposed to stabilize the diorganopalladium intermediate by coordination of the arene to the metal center. This cross-coupling is stereospecific with complete retention of stereochem.
Journal of the American Chemical Society published new progress about Acylation. 1435-43-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C6H3ClF2, Formula: C6H3ClF2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics