Montgomery, Justin I.; Toogood, Peter L.; Hutchings, Kim M.; Liu, Jia; Narasimhan, Lakshmi; Braden, Timothy; Dermyer, Michael R.; Kulynych, Angela D.; Smith, Yvonne D.; Warmus, Joseph S.; Taylor, Clarke published the artcile< Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase>, Name: Methyl 3-chloro-4-hydroxybenzoate, the main research area is ether benzyl aryl preparation bacterial phenylalanyl tRNA synthetase inhibitor.
A series of benzyl aryl ethers I (X = CH, N; R1 = 3-Cl, 4-Cl, 3,4-F2, 3,5-F2; R2 = H, Cl, Me; Y = CO2Me, SO2NMeCH2CH2NEt2, CONHCMeCH2OH, 1,3,4-oxadiazol-2-yl, etc.) that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase is described. The synthesis, SAR, and select ADMET data are provided.
Bioorganic & Medicinal Chemistry Letters published new progress about Alkyl aryl ethers Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 3-chloro-4-hydroxybenzoate.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics