Quality Control of Ethyl 3-(4-chlorophenyl)propanoateOn October 10, 2005 ,《Chemoselective Heck arylation of acrolein diethyl acetal catalyzed by an oxime-derived palladacycle》 was published in Tetrahedron. The article was written by Najera, Carmen; Botella, Luis. The article contains the following contents:
A dimeric 4-hydroxyacetophenone oxime-derived palladacycle has been used as a very efficient precatalyst for the chemoselective arylation of CH2:CH(OEt)2 (I) to give either cinnamaldehyde derivatives or 3-arylpropanoate esters by proper choice of the reaction conditions. The synthesis of cinnamaldehyde derivatives can be performed by Heck reaction of I with haloarenes in Me2NAc using K2CO3 as base at 120 °C and Bu4N OAc and KCl as additives, followed by acid workup. In the case of 3-arylpropanoate esters the arylation of I with iodoarenes can be performed at 90 °C in aqueous DMA using (dicyclohexyl)methylamine as base, whereas for bromoarenes the reaction has to be performed at 120 °C using Bu4NBr as additive. Alternatively, this process can be performed under microwave irradiation These couplings take place in good yields and with lower catalyst loading than with palladium(II) acetate as well as in shorter reaction times and with lower excess of I. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1Quality Control of Ethyl 3-(4-chlorophenyl)propanoate)
Ethyl 3-(4-chlorophenyl)propanoate(cas: 7116-36-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Quality Control of Ethyl 3-(4-chlorophenyl)propanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics