In 2019,Cell Chemical Biology included an article by Ohki, Yu; Sakurai, Hidetaka; Hoshino, Madoka; Terashima, Hideki; Shimizu, Hiroki; Ishikawa, Tomio; Ogiyama, Tomoko; Muramatsu, Yasunori; Nakanishi, Toshiyuki; Miyazaki, Shojiro; Tsuruoka, Hiroyuki; Kobayashi, Hideki; Kubota, Kazuishi. Recommanded Product: 768-35-4. The article was titled 《Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology》. The information in the text is summarized as follows:
Mol. target identification of small mols., so-called target deconvolution, is a major obstacle to phenotype-based drug discovery. Here, we developed an approach called perturbation-based proteomic correlation profiling (PPCP) utilizing the correlation between protein quantity and binding activity of compounds under cellular perturbation by gene silencing and successfully identified lanosterol synthase as a mol. target of TGF-β pathway inhibitor. This PPCP concept was extended to the use of a cell line panel and provides a new option for target deconvolution. The results came from multiple reactions, including the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Recommanded Product: 768-35-4)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Recommanded Product: 768-35-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics