Product Details of 5781-53-3In 2019 ,《Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes》 was published in ACS Catalysis. The article was written by Pitre, Spencer P.; Muuronen, Mikko; Fishman, Dmitry A.; Overman, Larry E.. The article contains the following contents:
Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited. This report describes the use of tert-alkyl oxalate salts, derived from tertiary alcs., to introduce tertiary substituents into a variety of heterocyclic substrates. This reaction has reasonably broad scope, proceeds rapidly under mild conditions, and is initiated by either photochem. or thermal activation. Insights into the underlying mechanism of the higher yielding visible-light initiated process were obtained by flash photolysis studies, whereas computational studies provided insight into the reaction scope. In the experiment, the researchers used Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Product Details of 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics