Pudnika, Linda; Domraceva, Ilona; Werner, Thomas; Zalubovskis, Raivis; Grandane, Aiga published their research in Synthesis in 2021. The article was titled 《Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones》.Synthetic Route of C6H6BFO2 The article contains the following contents:
A short and efficient synthetic route towards benzoxepine containing scaffold, which enables late stage modification was developed. Namely, base-free catalytic Wittig reactions enabled the synthesis of bromobenzoxepinones from readily available starting materials. Subsequent, Suzuki-Miyaura and Stille reactions proved to be suitable methods to access a variety of benzoxepinone diaryl derivatives by late stage modification in only three steps. This three-step reaction sequence was suitable for high throughput applications and gives facile access to highly complex mol. structures, which are suitable for further functionalization. The antiproliferative properties of selected arylbenzoxepinones were tested in-vitro on monolayer tumor cell line A549. Notably, in this initial screening, these compounds were found to be active in the micromolar range. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Synthetic Route of C6H6BFO2)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Synthetic Route of C6H6BFO2
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