Schnitzer, Tobias; Wennemers, Helma published the artcile< Deactivation of Secondary Amine Catalysts via Aldol Reaction-Amine Catalysis under Solvent-Free Conditions>, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is secondary amine catalyst deactivation aldol reaction; solvent free enantioselective conjugate addition.
Despite intense interest in amine-catalyzed stereoselective reactions, high catalyst loadings of ≥10 mol % are still common and either due to low reactivity or catalyst deactivation. Yet, few deactivation pathways are well understood. Here, we unraveled the deactivation of secondary amines by undesired aldol reaction. Mechanistic studies with peptide and prolinol silyl ether catalysts showed the generality of this so-far underappreciated catalyst deactivation pathway. The insights enabled conjugate addition reactions between aldehydes and nitroolefins on a multigram scale in the absence of solvent-conditions that are attractive as environmentally benign processes-with excellent product yields and stereoselectivities in the presence of as little as 0.1 mol % of a chemoselective peptidic catalyst.
Journal of Organic Chemistry published new progress about Addition reaction kinetics. 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Recommanded Product: (E)-1-Chloro-4-(2-nitrovinyl)benzene.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics